• J. Cutan. Pathol. · Aug 2005

    Case Reports

    Minocycline hyperpigmentation isolated to the subcutaneous fat.

    • Zakia Rahman, Rossitza Lazova, and Richard J Antaya.
    • Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520-8059, USA.
    • J. Cutan. Pathol. 2005 Aug 1; 32 (7): 516-9.

    AbstractWe present a 15-year-old girl with bilateral lower extremity discoloration of one-year duration while taking minocycline for acne vulgaris. The clinical characteristics best supported type II minocycline hyperpigmentation, but the histology revealed that the pigmentation was solely limited to the subcutaneous adipose tissue, completely sparing the dermis. Special stain for iron was negative. This is the first case to our knowledge with pigment exclusively located in the subcutaneous fat and with the unusual finding of a negative stain for iron.

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