• Philippe Gautret, Philippe Colson, Jean Christophe Lagier, Laurence Camoin-Jau, Audrey Giraud-Gatineau, Sophia Boudjema, Julie Finance, Hervé Chaudet, and Didier Raoult.
• IHU Méditerranée Infection, 19-21 boulevard Jean Moulin, 13005 Marseille, France; Aix Marseille Univ, Institut de Recherche pour le Développement (IRD), Assistance Publique - Hôpitaux de Marseille (AP-HM), Service de Santé des Armées (SSA), Vecteurs - Infections Tropicales et Méditerranéennes (VITROME), Marseille, France.
• Int. J. Infect. Dis. 2021 Jan 1; 102: 17-19.

ObjectiveTo describe the characteristics of COVID-19 patients seen in March-April and June-August 2020 in Marseille, France with the aim to investigate possible changes in the disease between these two time periods.MethodsDemographics, hospitalization rate, transfer to intensive care unit (ICU), lethality, clinical and biological parameters were investigated.ResultsCompared to those seen in March-April, COVID-19 patients seen in June-August were significantly younger (39.2 vs. 45.3 years), more likely to be male (52.9% vs. 45.6%), and less likely to be hospitalized (10.7 vs. 18.0%), to be transferred to ICU (0.9% vs. 1.8%) and to die (0.1% vs. 1.1%). Their mean fibrinogen and D-dimer blood levels were lower (1.0 vs. 1.5 g/L and 0.6 vs. 1.1 μg/mL, respectively). By contrast, their viral load was higher (cycle threshold ≤16 = 5.1% vs. 3.7%).ConclusionsPatients in the two periods did not present marked age and sex differences, but markers of severity were undoubtedly less prevalent in the summer period, associating with a 10 times decrease in the lethality rate.Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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