• Dtsch. Med. Wochenschr. · Dec 2020

    Review

    [Therapeutic drug monitoring of antiinfectives in intensive care unit patients - what's new?]

    • Christina König, Stefan Kluge, and Sebastian G Wicha.
    • Universitätsklinikum Hamburg-Eppendorf, Klinik für Intensivmedizin.
    • Dtsch. Med. Wochenschr. 2020 Dec 1; 145 (24): 1764-1769.

    AbstractPharmacokinetic and pharmacodynamic changes in intensive care unit patients can increase the risk for therapeutic failure or adverse effects of anti-infective therapy. Therapeutic drug monitoring (TDM) can inform required dose adaptions. The present article reviews the current practice and outlines modern approaches for decision making such as model-informed precision dosing software using the area-under-the-concentration-time-curve as target in favor of simplistic decision making based on trough concentrations. Moreover, the current recommendations for performing TDM of beta-lactams, aminoglycosides, linezolid, glycopeptides and voriconazole are concisely summarized.Thieme. All rights reserved.

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