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Dtsch. Med. Wochenschr. · Dec 2020
[Anemia and iron deficiency - treatment options in chronic kidney disease and in chronic heart failure].
- Insa E Emrich, Michael Böhm, and Gunnar H Heine.
- Klinik für Innere Medizin III, Klinik für Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinikum des Saarlandes, Homburg.
- Dtsch. Med. Wochenschr. 2020 Dec 1; 145 (24): 1775-1780.
AbstractAnemia and iron deficiency are highly prevalent in chronic kidney disease (CKD) and in chronic heart failure. Both may epidemiologically predict future renal and/or cardiovascular events. However, anemia treatment with either erythropoietin or erythropoiesis-stimulating agents failed to induce a prognostic benefit in either CKD or chronic heart failure. Instead, in the subgroup of chronic dialysis patients, liberal intravenous iron supplementation was beneficial, and ongoing clinical trials are testing the prognostic implication of intravenous iron supplementation in chronic heart failure. Finally, HIF stabilizers are a new treatment option for anemia in chronic kidney disease, and safety studies are currently ongoing in CKD patients. Whether patients suffering from chronic heart failure might also benefit from this treatment is currently unknown.Thieme. All rights reserved.
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