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Randomized Controlled Trial
Cost-effectiveness of pembrolizumab plus axitinib as first-line therapy for advanced renal cell carcinoma.
- Jiaxin Zhu, Tiantian Zhang, Ning Wan, Zhuoru Liang, Jiahao Li, Xudong Chen, Wenhua Liang, and Jie Jiang.
- College of Pharmacy, Jinan University, Guangzhou, China.
- Immunotherapy. 2020 Dec 1; 12 (17): 1237-1246.
AbstractAim: To evaluate the cost-effectiveness of first-line treatments for advanced renal cell carcinoma with pembrolizumab plus axitinib compared with sunitinib from the US payer perspective. Patients & methods: A Markov model was developed for this purpose. The clinical data were obtained from the KEYNOTE-426 trial. Utility values and direct costs related to the treatments were gathered from the published studies. Results: The incremental cost-effectiveness ratios of pembrolizumab plus axitinib versus sunitinib was $249,704 per quality-adjusted life year, which was higher than a willingness-to-pay threshold of $150,000 per quality-adjusted life year. Conclusion: Pembrolizumab plus axitinib was not considered to be cost-effective versus sunitinib as a first-line treatment for patients with advanced renal cell carcinoma from the US payer perspective.
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