• Masoumeh Zirak Javanmard, Khadije Meghrazi, Sayed Soran Ghafori, and Mojtaba Karimipour.
• Department of Anatomy, Urmia University of Medical Sciences, Urmia, IR Iran.
• J Res Med Sci. 2020 Jan 1; 25: 91.

BackgroundThe production of stress oxidative condition in body which is caused by consumption of ecstasy (3,4-methylenedioxymethamphetamine [MDMA]) leads to a liver damage. As an antioxidant, Vitamin E can protect cells and tissues against the deleterious effects of free radicals. This study evaluates the protective effects of Vitamin E on MDMA induced liver toxicity.Materials And MethodsTwenty-eight male albino mice were randomly assigned to four equal groups. Group 1 received saline (control), Group 2 received MDMA and saline, Group 3 received MDMA, and Vitamin E and Group 4 received Vitamin E. MDMA was injected with single daily dose, three sequential days/week for 5 weeks. At the end of the period, blood samples were collected for a biochemical analysis and then the mice were sacrificed by cervical dislocation for histopathological and biochemical examinations of liver.ResultsThe administration of Vitamin E attenuated the increased levels of alanine transaminase, aspartate transaminase, and alkaline phosphatase enzymes in serum. Vitamin E treatments significantly restored endogenous antioxidant enzymes (reduced glutathione and superoxide dismutase enzyme) activities as compared with MDMA-treated animals. Histological examination of liver revealed significant morphological tissue injuries in hepatocytes after MDMA being used, but in coadministration of vitamin E and MDMA, these morphological alterations reduced.ConclusionThe study showed that MDMA administration has adverse effects on the liver. Vitamin E lessened the deleterious impact considerably.Copyright: © 2020 Journal of Research in Medical Sciences.

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