• The Journal of infection · Jun 2020

    Review

    The pathogenesis and treatment of the `Cytokine Storm' in COVID-19.

    • Qing Ye, Bili Wang, and Jianhua Mao.
    • National Clinical Research Center for Child Health, National Children's Regional Medical Center, the Children's Hospital, Zhejiang University School of Medicine, No 3333, Binsheng Road, Hangzhou 310052, China.
    • J. Infect. 2020 Jun 1; 80 (6): 607-613.

    AbstractCytokine storm is an excessive immune response to external stimuli. The pathogenesis of the cytokine storm is complex. The disease progresses rapidly, and the mortality is high. Certain evidence shows that, during the coronavirus disease 2019 (COVID-19) epidemic, the severe deterioration of some patients has been closely related to the cytokine storm in their bodies. This article reviews the occurrence mechanism and treatment strategies of the COVID-19 virus-induced inflammatory storm in attempt to provide valuable medication guidance for clinical treatment.Copyright © 2020 Elsevier Ltd. All rights reserved.

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