• Wei-Guang Guo, Bin Fang, Yan-Shan Xian, Zhi-Hui Yu, and Li-Xin Zhou.
• Department of Critical Care Medicine of Foshan first people's Hospital, Foshan, 528000, Guangdong Province, China.
• Medicine (Baltimore). 2020 Dec 4; 99 (49): e23160.

IntroductionAcute respiratory distress syndrome (ARDS) secondary to COVID-19 is different from the ARDS caused by other infections. Conventional mechanical ventilation strategies using high levels of PEEP may not be beneficial and can even be harmful to patient with ARDS from COVID-19. So the ventilation strategies should be adjusted in order to improve the pulmonary ventilation function and oxygenation status, and outcomes of the patient.Patient ConcernsHerein, we present a 76-year-old male patient with ARDS secondary to COVID-19. We describe our experience with mechanical ventilation strategy and the changes in respiratory mechanics in the patient during treatment.DiagnosisThe patient had tested positive for coronavirus (COVID-19) in nucleic acid test. Chest CT showed multiple ground glass shadows in both lungs.InterventionsThe patient received mechanical ventilation with low tidal volume and low PEEP.OutcomesAfter treatment, the patients condition, as well as oxygenation status was improved, and he tested negative for the coronavirus several times.ConclusionThis case demonstrated that the low tidal volume with low levels of PEEP ventilation strategy may be more suitable for ARDS from COVID-19.

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