• Best Pract Res Clin Anaesthesiol · Dec 2020

    Review

    Is there a place for genetics in the management of PONV?

    • Keith Candiotti, Chandrama Shrestha, and Mariana Rubini Silva Ceschim.
    • Department of Anesthesiology, Perioperative Medicine and Pain Management, University of Miami, Miller School of Medicine, Miami, FL, 1611 NW 12th Ave, Suite C300, Miami, FL, 33136, USA. Electronic address: KCandiot@med.miami.edu.
    • Best Pract Res Clin Anaesthesiol. 2020 Dec 1; 34 (4): 713-720.

    AbstractAntiemetic prophylaxis for postoperative nausea and vomiting (PONV) - a frequent complication in the postoperative period - is routinely given to high-risk patients. However, standard PONV risk models do not account for genetic factors, which have been shown to have a significant influence on PONV incidence and drug response. In this review, we describe the polymorphisms of various genes (serotonin, dopamine, cholinergic, etc.) and how pharmacogenomics is involved in the pathophysiology of PONV. This review also addresses how genetics is involved in today's clinical practice related to PONV and how it will change in the upcoming years as personalized medicine advances.Copyright © 2020 Elsevier Ltd. All rights reserved.

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