The next generation of antiemetics for the management of

Best Pract Res Clin Anaesthesiol · Dec 2020

Review

The next generation of antiemetics for the management of postoperative nausea and vomiting.

Postoperative nausea and vomiting (PONV) afflict approximately 30% of patients overall and up to 80% of high-risk patients after surgery. Optimal pharmacological prophylaxis of PONV is challenging as it necessitates the consideration of PONV risk, drug efficacy, and potential adverse effects. ⋯ Newer antiemetics have been introduced that may have improved safety profiles, longer duration of action, and better efficacy. This review aims to summarize the recent developments pertaining to these new agents and their potential application toward the management of PONV.

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- Hon Sen Tan, Geertrui Dewinter, and Ashraf S Habib.
- Department of Women's Anesthesia, KK Women's and Children's Hospital, 100 Bukit Timah Road, 229899, Singapore.
- Best Pract Res Clin Anaesthesiol. 2020 Dec 1; 34 (4): 759-769.
AbstractPostoperative nausea and vomiting (PONV) afflict approximately 30% of patients overall and up to 80% of high-risk patients after surgery. Optimal pharmacological prophylaxis of PONV is challenging as it necessitates the consideration of PONV risk, drug efficacy, and potential adverse effects. Despite significant advances in our understanding of the pathophysiology and risk factors of PONV, its incidence has remained largely unchanged. Newer antiemetics have been introduced that may have improved safety profiles, longer duration of action, and better efficacy. This review aims to summarize the recent developments pertaining to these new agents and their potential application toward the management of PONV.Copyright © 2020 Elsevier Ltd. All rights reserved.

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The next generation of antiemetics for the management of postoperative nausea and vomiting.

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