• Gilles Kayem, Edouard Lecarpentier, Philippe Deruelle, Florence Bretelle, Elie Azria, Julie Blanc, Caroline Bohec, Marie Bornes, Pierre-François Ceccaldi, Yasmine Chalet, Céline Chauleur, Anne-Gael Cordier, Raoul Desbrière, Muriel Doret, Michel Dreyfus, Marine Driessen, Marion Fermaut, Denis Gallot, Charles Garabédian, Cyril Huissoud, Dominique Luton, Olivier Morel, Franck Perrotin, Olivier Picone, Patrick Rozenberg, Loïc Sentilhes, Jeremy Sroussi, Christophe Vayssière, Eric Verspyck, Alexandre J Vivanti, Norbert Winer, Vivien Alessandrini, and Thomas Schmitz.
• Assistance Publique-Hôpitaux de Paris, 75004, Paris, France. Electronic address: gkayem@gmail.com.
• J Gynecol Obstet Hum Reprod. 2020 Sep 1; 49 (7): 101826.

ObjectiveTo describe the course over time of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in French women from the beginning of the pandemic until mid-April, the risk profile of women with respiratory complications, and short-term pregnancy outcomes.MethodsWe collected a case series of pregnant women with COVID-19 in a research network of 33 French maternity units between March 1 and April 14, 2020. All cases of SARS-CoV-2 infection confirmed by a positive result on real-time reverse transcriptase polymerase chain reaction tests of a nasal sample and/or diagnosed by a computed tomography chest scan were included and analyzed. The primary outcome measures were COVID-19 requiring oxygen (oxygen therapy or noninvasive ventilation) and critical COVID-19 (requiring invasive mechanical ventilation or extracorporeal membrane oxygenation, ECMO). Demographic data, baseline comorbidities, and pregnancy outcomes were also collected.ResultsActive cases of COVID-19 increased exponentially during March 1-31, 2020; the numbers fell during April 1-14, after lockdown was imposed on March 17. The shape of the curve of active critical COVID-19 mirrored that of all active cases. By April 14, among the 617 pregnant women with COVID-19, 93 women (15.1 %; 95 %CI 12.3-18.1) had required oxygen therapy and 35 others (5.7 %; 95 %CI 4.0-7.8) had had a critical form of COVID-19. The severity of the disease was associated with age older than 35 years and obesity, as well as preexisting diabetes, previous preeclampsia, and gestational hypertension or preeclampsia. One woman with critical COVID-19 died (0.2 %; 95 %CI 0-0.9). Among the women who gave birth, rates of preterm birth in women with non-severe, oxygen-requiring, and critical COVID-19 were 13/123 (10.6 %), 14/29 (48.3 %), and 23/29 (79.3 %) before 37 weeks and 3/123 (2.4 %), 4/29 (13.8 %), and 14/29 (48.3 %) before 32 weeks, respectively. One neonate (0.5 %; 95 %CI 0.01-2.9) in the critical group died from prematurity.ConclusionCOVID-19 can be responsible for significant rates of severe acute, potentially deadly, respiratory distress syndromes. The most vulnerable pregnant women, those with comorbidities, may benefit particularly from prevention measures such as a lockdown.Copyright © 2020 Elsevier Masson SAS. All rights reserved.

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