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- Leo F Buckley, George F Wohlford, Clara Ting, Abdullah Alahmed, Benjamin W Van Tassell, Antonio Abbate, John W Devlin, and Peter Libby.
- Department of Pharmacy Services, Brigham and Women's Hospital, Boston, MA.
- Crit Care Explor. 2020 Aug 1; 2 (8): e0178.
AbstractThe causative agent for coronavirus disease 2019, severe acute respiratory syndrome coronavirus 2, appears exceptional in its virulence and immunopathology. In some patients, the resulting hyperinflammation resembles a cytokine release syndrome. Our knowledge of the immunopathogenesis of coronavirus disease 2019 is evolving and anti-cytokine therapies are under active investigation. This narrative review summarizes existing knowledge of the immune response to coronavirus infection and highlights the current and potential future roles of therapeutic strategies to combat the hyperinflammatory response of patients with coronavirus disease 2019.Copyright © 2020 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine.
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