• Am. J. Med. · Apr 2021

    Life's Simple 7 and Non-Alcoholic Fatty Liver Disease: The Multi-Ethnic Study of Atherosclerosis.

    • Ebenezer Oni, Oluseye Ogunmoroti, Norrina Allen, Mouaz H A-Mallah, Ron Blankstein, Seth S Martin, Irfan Zeb, Mary Cushman, Parag H Joshi, Matthew J Budoff, Michael J Blaha, Roger S Blumenthal, Emir Veledar, and Khurram Nasir.
    • Division of Cardiology, Heart and Vascular Institute, Albert Einstein Medical Center, Philadelphia, Penn. Electronic address: ebenezeroni2@gmail.com.
    • Am. J. Med. 2021 Apr 1; 134 (4): 519-525.

    BackgroundThe American Heart Association (AHA) has defined Life's Simple 7 (LS7) as a measure of overall cardiovascular health . Nonalcoholic fatty liver disease (NAFLD) has been involved as a risk factor for cardiovascular disease. We evaluated the association between LS7 and NAFLD.MethodsWe evaluated participants form the Multi-Ethnic Study of Atherosclerosis (MESA) cohort. Cardiovascular health score was calculated from the Life's Simple 7 metrics. A score of 0-8 was considered inadequate, 9-10 average, and 11-14 optimal. NAFLD was defined using noncontrast cardiac computed tomography (CT) and a liver/spleen attenuation ratio (L/S) < 1. Multivariable regression were performed to evaluate the association.ResultsOur cross-sectional analysis of 3901 participants showed 19% (n = 747) had optimal cardiovascular health, 33% (n = 1270) had average, and 48% (n = 1884) had inadequate. White participants were most likely to have an optimal score (51%, n = 378), whereas African American participants had the lowest proportion with optimal scores (16%, n = 120; P < 0.001). The overall prevalence of NAFLD was 18% with a distribution of 7%, 14%, and 25% in the optimal, average, and inadequate score categories, respectively (P < 0.001). Adjusted for risk factors, average and optimal health categories had lower odds of NAFLD compared to those with inadequate scores: odds ratio for average, 0.44 (95% confidence interval 0.36-0.54); optimal, odds ratio 0.19 (95% confidence interval 0.14-0.26). This association was similar across gender, race and age groups.ConclusionA more favorable cardiovascular health score was associated with a lower prevalence of NAFLD. This study may suggest a potential of Life's Simple 7 in the prevention of liver disease.Copyright © 2020 Elsevier Inc. All rights reserved.

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