• Vedat Acik, Ozgur Kulahcı, Ali Arslan, İsmail İstemen, Semih Kivanc Olguner, Baris Arslan, Yurdal Gezercan, and Ali İhsan Ökten.
• Department of Neurosurgery, Adana City Training and Research Hospital, Adana, Turkey. Electronic address: vedatacik74@gmail.com.
• World Neurosurg. 2021 Mar 1; 147: e105-e110.

ObjectiveIn this study, we aimed to examine the effect of myeloperoxidase on aneurysm rupture in patients with cerebral aneurysms with and without rupture.MethodsThe study included 53 patients with subarachnoid hemorrhage operated on due to cerebral aneurysm in our clinic, and 49 patients without subarachnoid hemorrhage. After the operation, the domes taken from the aneurysms were embedded in paraffin blocks and scored after hematoxylin and eosin and immunohistochemical staining was carried out.ResultsThe myeloperoxidase score was 1 in 29.4% of the patients, 2 in 40.2%, 3 in 12.7%, and 4 in 17.6%. Multiple aneurysms were detected in 24.5% of the patients. The median myeloperoxidase score was higher in patients with bleeding aneurysms than those that did not bleed (3 vs. 1; P < 0.001). In addition, the ratio of patients with a myeloperoxidase score of 2 or above was higher among patients with bleeding aneurysms.ConclusionsIn our study, finding myeloperoxidase scores higher in cases of ruptured aneurysms compared with unruptured aneurysms reveals the relationship of myeloperoxidase with ruptured cerebral aneurysms.Copyright © 2020 Elsevier Inc. All rights reserved.

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