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Case Reports
[Acute respiratory distress syndrome as the presenting manifestation of an antisynthetase syndrome].
- D Fagedet, S Bernard, B Colombe, A Bosseray, A Baudet, L Bouillet, and C Massot.
- Clinique de médecine interne, CHU de Grenoble, BP 217, 38700 la Tronche cedex 09, France. dfagedet@yahoo.fr
- Rev Med Interne. 2009 Jul 1; 30 (7): 634-6.
AbstractThe antisynthetase syndrome is a subgroup of idiopathic inflammatory muscle diseases. Its characteristics are interstitial lung disease, myositis, polyarthritis, mechanic's hand like cutaneous involvement, and the presence of antisynthetase antibodies (anti-Jo1). The lung disease is the presenting feature in 50% of cases. We report a patient with an antisynthetase syndrome, revealed by an acute respiratory distress syndrome. This patient was already followed-up for a scleroderma and presented a probable overlap syndrome. The disease course was favourable with anti-CD20 therapy.
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