• O Gisserot, E Romeo, L Boudin, P Tsitsi Nding Tsogou, S Abed, J-S Bladé, and J-P de Jauréguiberry.
• Service de médecine interne-oncologie, hôpital d'instruction des armées Sainte-Anne, BP 600, 83800 Toulon cedex 9, France. Electronic address: oncologie@sainteanne.org.
• Rev Med Interne. 2014 Apr 1; 35 (4): 259-63.

AbstractInfections are an important cause of cancer in the world, representing approximately 16% of the neoplasia. Ten infectious agents have been classified as carcinogens of group I. Four of these pathogens (Helicobacter pylori, hepatitis B and C viruses, and some human papillomavirus) are responsible for 95% of cases of infection-related cancers. The carcinogenesis mechanisms are multiple, either direct via certain proteins from these microorganisms, or more often indirect through chronic inflammation. This allowed to consider prevention of certain cancers, for example with a prophylactic vaccine strategy. Advances were also made in the curative field. However, efforts remain to be done to discover new infectious causes of cancer and refine the understanding of the mechanisms of carcinogenesis, for a better targeting of anticancer therapeutics.Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

32 keywords...

hide…