• Curr Opin Crit Care · Apr 2002

    Review

    Lung injury in acute pancreatitis: mechanisms, prevention, and therapy.

    • Conor J Shields, Desmond C Winter, and H Paul Redmond.
    • Department of Academic Surgery, Cork University Hospital, and National University of Ireland, Cork, Ireland.
    • Curr Opin Crit Care. 2002 Apr 1; 8 (2): 158-63.

    AbstractLung injury is the most pertinent manifestation of extra-abdominal organ dysfunction in pancreatitis. The propensity of this retroperitoneal inflammatory condition to engender a diffuse and life-threatening lung injury is significant. Approximately one third of patients will develop acute lung injury and acute respiratory distress syndrome, which account for 60% of all deaths within the first week. The variability in the clinical course of pancreatitis renders it a vexing entity and makes demonstration of the efficacy of any specific intervention difficult. The distinct pathologic entity of pancreatitis-associated lung injury is reviewed with a focus on etiology and potential therapeutic maneuvers.

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