• Rev Assoc Med Bras (1992) · Nov 2020

    Evaluation of peptidylarginine deiminase 4 and PADI4 polymorphisms in sepsis-induced acute kidney injury.

    • Nara Aline Costa, Bertha Furlan Polegato, Amanda Gomes Pereira, Sérgio Alberto Rupp de Paiva, Ana Lúcia Gut, André Luís Balbi, Daniela Ponce, Zornoff Leonardo Antonio Mamede LAM http://orcid.org/0000-0002-9831-8820 Professor Titular da Faculdade de Medicina de Botucatu - Unesp, Botucatu, SP,, Paula Schmidt Azevedo, and Marcos Ferreira Minicucci.
    • Professora Adjunta da Faculdade de Nutrição da Universidade Federal de Goiás - UFG, Goiania, GO, Brasil.
    • Rev Assoc Med Bras (1992). 2020 Nov 1; 66 (11): 1515-1520.

    BackgroundThe aim of this study is to evaluate the peptidylarginine deiminase 4 (PAD 4) concentration and PADI4 polymorphisms as predictors of acute kidney injury (AKI) development, the need for renal replacement therapy (RRT), and mortality in patients with septic shock.MethodsWe included all individuals aged ≥ 18 years, with a diagnosis of septic shock at ICU admission. Blood samples were taken within the first 24 hours of the patient's admission to determine serum PAD4 concentration and its PADI4 polymorphism (rs11203367) and (rs874881). Patients were monitored during their ICU stay and the development of SAKI was evaluated. Among the patients in whom SAKI developed, mortality and the need for RRT were also evaluated.ResultsThere were 99 patients, 51.5% of whom developed SAKI and of these, 21.5% needed RRT and 80% died in the ICU. There was no difference between PAD4 concentration (p = 0.116) and its polymorphisms rs11203367 (p = 0.910) and rs874881 (p = 0.769) in patients in whom SAKI did or did not develop. However, PAD4 had a positive correlation with plasma urea concentration (r = 0.269 and p = 0.007) and creatinine (r = 0.284 and p = 0.004). The PAD4 concentration and PADI4 polymorphisms were also not associated with RRT and with mortality in patients with SAKI.ConclusionPAD4 concentration and its polymorphisms were not associated with SAKI development, the need for RRT, or mortality in patients with septic shock. However, PAD4 concentrations were associated with creatinine and urea levels in these patients.

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