• Internal medicine journal · Aug 2020

    Case Reports

    Nivolumab-associated myositis myocarditis and myasthenia and anti-striated muscle antibodies.

    • Marium Fazal, David A Prentice, Lay K Kho, and Edward Fysh.
    • General Medicine Department, St John of God Midland Public Hospital, Perth, Western Australia, Australia.
    • Intern Med J. 2020 Aug 1; 50 (8): 1003-1006.

    AbstractAn 82-year-old man was treated with neo-adjuvant nivolumab (programmed cell death protein 1 or PD-1 inhibitor) for local recurrence of melanoma developed myositis, myocarditis and a myasthenic-like syndrome with a fatal outcome. The occurrence of these three conditions may constitute a new immune checkpoint-induced syndrome. The relevance of the clinical features and the immunology is discussed. This case highlights the special role of anti-striated muscle antibodies as a predictor of mortality.© 2020 Royal Australasian College of Physicians.

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