• Br J Surg · Sep 1988

    Neutrophil degranulation and increased pulmonary capillary permeability following oesophagectomy: a model of early lung injury in man.

    • G M Rocker, M S Wiseman, D Pearson, and D J Shale.
    • Respiratory Medicine Unit, City Hospital, Nottingham, UK.
    • Br J Surg. 1988 Sep 1; 75 (9): 883-6.

    AbstractIn nine subjects undergoing oesophagectomy a transient but significant increase in pulmonary vascular permeability to transferrin was detected in both lungs 8 h after surgery. It coincided with a significant increase in plasma lactoferrin, evidence of intravascular and intra-alveolar neutrophil elastase release and with arterial hypoxaemia. The postoperative state in these patients had intravascular and pulmonary features often associated with the adult respiratory distress syndrome, and might be a useful model for the study of the early inflammatory events underlying lung injury in man.

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