• Am. J. Med. Sci. · Aug 2009

    Case Reports

    Rifampin-associated pseudomembranous colitis.

    • Tun-Chieh Chen, Po-Liang Lu, Wei-Ru Lin, Chun-Yu Lin, Jeng-Yih Wu, and Yen-Hsu Chen.
    • Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan.
    • Am. J. Med. Sci. 2009 Aug 1; 338 (2): 156-8.

    AbstractPseudomembranous colitis (PMC) is known to develop after antibiotic treatment, but is rarely associated with antituberculosis (anti-TB) agents. We report a 28-year-old woman without underlying diseases developing PMC after 126 days of anti-TB treatment. Severe diarrhea and abdominal cramping pain were experienced. Colonoscopic biopsy proved the diagnosis of PMC. Her symptoms improved after discontinuing the anti-TB agents but recurred shortly after challenging with rifampin and isoniazid. Metronidazole administration and replacement of rifampin with levofloxacin successfully cured the PMC. Our report supports the notion that rifampin can induce PMC.

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