• Oktay Irkorucu, Bulent Hamdi Ucan, Guldeniz Karadeniz Cakmak, Oge Tascilar, Ali Ugur Emre, Ebru Ofluoglu, Burak Bahadir, Kemal Karakaya, Canan Demirtas, Hatice Pasaoglu, Handan Ankarali, and Mustafa Comert.
• Department of General Surgery, Zonguldak Karaelmas University, Medical School Zonguldak, Turkey. oktaytip@yahoo.com
• J Invest Surg. 2009 May 1; 22 (3): 188-94.

Introduction2-octyl-cyanoacrylate may be a good alternative in ischemic colon anastomosis without impairment of tissue perfusion.MethodsForty male Wistar albino rats were randomized into four experimental groups (n = 10 in each group). In group 1 (control), a well-perfused left colonic segment was transected, and free ends were anastomosed by propylene sutures. In groups 2, 3, and 4, the animals underwent a standardized surgical procedure to induce ischemic left colon anastomosis. In group 2, an end-to-end anastomosis was created using six interrupted 6-0 polypropylene sutures between ischemic edges. In group 3, after approximating the mesenteric and antimesenteric edges of the anastomosis with two 6-0 polypropylene sutures, 2-octyl-cyanoacrylate was applied between the edges. In group 4, anastomosis was created by the same technique as described in group 2, and additionally 2-octyl-cyanoacrylate was applied on suture line. Rats were killed on day 4 following operation. Anastomotic integrity, intraperitoneal adhesion scores, anastomotic bursting pressures, and tissue hydroxyproline levels were recorded. Histopathological examination of the anastomosis was also performed.ResultsThere were no statistically significant differences among groups with respect to anastomotic integrity (p =.142). The mean bursting pressure values were 81.1 +/- 23.83, 43.3 +/- 26.06, 15.8 +/- 11.3, and 17.6 +/- 18.02 in groups 1, 2, 3, and 4, respectively. There were no statistically significant differences among groups 2, 3, and 4 with respect to tissue hydroxyproline levels and bursting pressure levels. The highest adhesion scores were observed in groups 3 and 4.Discussion2-octyl cyanoacrylate does not have additional advantages in the healing of experimental ischemic colon anastomosis.

27 keywords...

hide…