• J Pain Palliat Care Pharmacother · Jan 2005

    Review

    Aprepitant (EMEND): the role of substance P in nausea and vomiting.

    • Eric Prommer.
    • UCLA School of Medicine, Division of Hematology/Oncology, Los Angeles, CA 90073, USA. eric.prommer@med.va.gov
    • J Pain Palliat Care Pharmacother. 2005 Jan 1; 19 (3): 31-9.

    AbstractAprepitant (EMEND) is the first commercially available drug from a new class of agents, the Substance P/neurokinin NK-1 receptor antagonists. Aprepitant is indicated for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) associated with highly emetogenic chemotherapy in adults. Its ability to antagonize the effects of Substance P has lead to greater understanding of the pathophysiology of nausea and vomiting. Its broad range of activity against a wide variety of central and peripheral emetogenic stimuli make it potentially useful in non-chemotherapy related nausea and vomiting.

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