Aprepitant: an oral NK1 antagonist for the prevention of nausea

Drugs of today · Oct 2004

Review

Aprepitant: an oral NK1 antagonist for the prevention of nausea and vomiting induced by highly emetogenic chemotherapy.

This paper reviews the clinical profile of aprepitant, the first neurokinin-1 (NK(1)) receptor antagonist to be approved for use in the prevention of chemotherapy-induced nausea and vomiting. When given to patients receiving highly emetogenic chemotherapy, aprepitant in combination with a 5-hydroxytryptamine type-3 (5HT(3)) receptor antagonist and a corticosteroid provides significantly improved protection from chemotherapy-induced nausea and vomiting over that which has been previously achievable with current antiemetics.

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- Kelly Pendergrass, Richard Hargreaves, Kevin J Petty, Alexandra D Carides, Judith K Evans, and Kevin J Horgan.
- Kansas City Cancer Center - South, 1000 East 101st Street Terrace, Kansas City, Missouri 60131, USA. kelly.pendergrass@usoncology.com
- Drugs Today. 2004 Oct 1; 40 (10): 853-63.
AbstractThis paper reviews the clinical profile of aprepitant, the first neurokinin-1 (NK(1)) receptor antagonist to be approved for use in the prevention of chemotherapy-induced nausea and vomiting. When given to patients receiving highly emetogenic chemotherapy, aprepitant in combination with a 5-hydroxytryptamine type-3 (5HT(3)) receptor antagonist and a corticosteroid provides significantly improved protection from chemotherapy-induced nausea and vomiting over that which has been previously achievable with current antiemetics.Copyright 2004 Prous Science.

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Aprepitant: an oral NK1 antagonist for the prevention of nausea and vomiting induced by highly emetogenic chemotherapy.

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