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Case Reports
Amphotericin B-associated hyperbilirubinemia: case report and review of the literature.
- Jacqueline L Olin and Linda M Spooner.
- Department of Pharmacy Practice and Administration, Ernest Mario School of Pharmacy-Rutgers, State University of New Jersey, Piscataway 08854-8020, USA. jlolin@rci.rutgers.edu
- Pharmacotherapy. 2006 Jul 1; 26 (7): 1011-7.
AbstractA 53-year-old woman with an intraabdominal infection secondary to Candida albicans experienced hyperbilirubinemia after receiving amphotericin B in two different formulations--amphotericin B deoxycholate and amphotericin B lipid complex. Only a few case reports of amphotericin B-induced hyperbilirubinemia have been documented in the literature, each with different patterns of corresponding abnormalities in liver function tests. The unpredictable nature of this adverse effect warrants monitoring of bilirubin levels and liver function at baseline and potentially during therapy with amphotericin B, regardless of formulation, dosage, or duration of therapy.
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