• Yaping Wang, Baolin Liao, Yan Guo, Feng Li, Chunliang Lei, Fuchun Zhang, Weiping Cai, Wenxin Hong, Yu Zeng, Shuang Qiu, Jian Wang, Yueping Li, Xilong Deng, Jianping Li, Guangming Xiao, Fengxia Guo, Xunxi Lai, Zhiwei Liang, Xueliang Wen, Pinghong Li, Qian Jiao, Fangfei Xiang, Yong Wang, Chenghui Ma, Zhiwei Xie, Weiyin Lin, Yanrong Wu, Xiaoping Tang, Linghua Li, and Yujuan Guan.
• Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
• Open Forum Infect Dis. 2020 Jun 1; 7 (6): ofaa187.

BackgroundThe clinical manifestations and factors associated with the severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections outside of Wuhan are not clearly understood.MethodsAll laboratory-confirmed cases with SARS-Cov-2 infection who were hospitalized and monitored in Guangzhou Eighth People's Hospital were recruited from January 20 to February 10.ResultsA total of 275 patients were included in this study. The median patient age was 49 years, and 63.6% had exposure to Wuhan. The median virus incubation period was 6 days. Fever (70.5%) and dry cough (56.0%) were the most common symptoms. A decreased albumin level was found in 51.3% of patients, lymphopenia in 33.5%, and pneumonia based on chest computed tomography in 86%. Approximately 16% of patients (n = 45) had severe disease, and there were no deaths. Compared with patients with nonsevere disease, those with severe disease were older, had a higher frequency of coexisting conditions and pneumonia, and had a shorter incubation period (all P < .05). There were no differences between patients who likely contacted the virus in Wuhan and those who had no exposure to Wuhan. Multivariate logistic regression analysis indicated that older age, male sex, and decreased albumin level were independently associated with disease severity.ConclusionsMost of the patients infected with SARS-CoV-2 in Guangzhou, China are not severe cases and patients with older age, male, and decreased albumin level were more likely to develop into severe ones.© The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America.

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