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Med. Clin. North Am. · Jan 2017
ReviewLocal Renin Angiotensin Aldosterone Systems and Cardiovascular Diseases.
- Walmor C De Mello.
- Department of Pharmacology, School of Medicine, Medical Sciences Campus, UPR, San Juan, PR 00936, USA. Electronic address: walmor.de-mello@upr.edu.
- Med. Clin. North Am. 2017 Jan 1; 101 (1): 117-127.
AbstractThe presence of local renin angiotensin aldosterone systems (RAAS) in the cardiovascular and renal tissues and their influence in cardiovascular and renal diseases are described. The fundamental role of ACE/Ang II/AT1 receptor axis activation as well the counterregulatory role of ACE2/Ang (1-7)/Mas receptor activation on cardiovascular and renal physiology and pathology are emphasized. The presence of a local RAS and its influence on hypertension is discussed, and finally, the hypothesis that epigenetic factors change the RAAS in utero and induce the expression of renin or Ang II inside the cells of the cardiovascular system is presented.Copyright © 2016 Elsevier Inc. All rights reserved.
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