• Antimicrob. Agents Chemother. · Dec 2014

    Administration of a triple versus a standard double antimicrobial regimen for human brucellosis more efficiently eliminates bacterial DNA load.

    • Georgia Vrioni, Adamantios Bourdakis, Georgios Pappas, Vassiliki Pitiriga, Maria Mavrouli, Spyros Pournaras, and Athanassios Tsakris.
    • Department of Microbiology, Medical School, University of Athens, Athens, Greece.
    • Antimicrob. Agents Chemother. 2014 Dec 1; 58 (12): 7541-4.

    AbstractThe effects of doxycycline-streptomycin-rifampin versus a standard doxycycline-streptomycin regimen on residual Brucella DNA were compared in 36 acute brucellosis patients. At admission, all patients given triple (n = 22) and double (n = 14) regimens had detectable Brucella DNA with similar mean loads (P = 0.982). At follow-up, 14 to 20 months postpresentation, significantly more patients receiving triple than double regimens had undetectable Brucella DNA (P = 0.026). The doxycycline-streptomycin-rifampin regimen eliminates Brucella DNA more efficiently than doxycycline-streptomycin, which may result in superior long-term clearance of Brucella. Copyright © 2014, American Society for Microbiology. All Rights Reserved.

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