• Ioan-Alexandru Minciună, Hilda OrășanOlgaOhttps://orcid.org/0000-0003-4435-142XInternal Medicine Department, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania., Iulia Minciună, Andrada-Luciana Lazar, Adela Viviana Sitar-Tăut, Monica Oltean, Raluca Tomoaia, Mihai Puiu, Dan-Andrei Sitar-Tăut, Dana Pop, and Angela Cozma.
• "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
• Eur. J. Clin. Invest. 2021 Apr 1; 51 (4): e13475.

BackgroundDiastolic dysfunction is traditionally believed to be the first subclinical manifestation of diabetic cardiomyopathy (DCM), leading to systolic dysfunction and then overt heart failure. However, in the last few years, several studies suggested that systolic subclinical dysfunction measured by speckle-tracking echocardiography (STE) may appear ahead of diastolic dysfunction. In this review, the main endpoint is to show whether subclinical myocardial systolic dysfunction appears ahead of diastolic dysfunction and the implication this may have on the evolution and management of DCM.Materials And MethodsWe performed a search in PubMed for all relevant publications on the assessment of DCM by STE from 1 June 2015 to 1 June 2020.Results And ConclusionsThe results illustrate that subclinical systolic dysfunction assessed by STE is present in early DCM stages, with or without the association of diastolic dysfunction. This could be a promising perspective for the early management of patients with DCM leading to the prevention of the overt form of disease.© 2020 Stichting European Society for Clinical Investigation Journal Foundation. Published by John Wiley & Sons Ltd.

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