• Timothy E Miller, Monty Mythen, Andrew D Shaw, Seungyoung Hwang, Apeksha V Shenoy, Michael Bershad, and Charles Hunley.
• Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA.
• Br J Anaesth. 2021 Mar 1; 126 (3): 720-729.

BackgroundPostoperative complications increase hospital length of stay and patient mortality. Optimal perioperative fluid management should decrease patient complications. This study examined associations between fluid volume and noncardiac surgery patient outcomes within a large multicentre US surgical cohort.MethodsAdults undergoing noncardiac procedures from January 1, 2012 to December 31, 2017, with a postoperative length of stay ≥24 h, were extracted from a large US electronic health record database. Patients were segmented into quintiles based on recorded perioperative fluid volumes with Quintile 3 (Q3) serving as the reference. The primary outcome was defined as a composite of any complications during the surgical admission and a postoperative length of stay ≥7 days. Secondary outcomes included in-hospital mortality, respiratory complications, and acute kidney injury.ResultsA total of 35 736 patients met the study criteria. There was a U-shaped pattern with highest (Q5) and lowest (Q1) quintiles of fluid volumes having increased odds of complications and a postoperative length of stay ≥7 days (Q5: odds ratio [OR] 1.51 [95% confidence interval {CI}: 1.30-1.74], P<0.001; Q1: OR 1.20 [95% CI: 1.04-1.38], P=0.011) compared with Q3. Patients in Q5 had greater odds of more severe acute kidney injury compared with Q3 (OR 1.52 [95% CI: 1.22-1.90]; P<0.001) and respiratory complications (OR 1.44 [95% CI: 1.17-1.77]; P<0.001).ConclusionsBoth very high and very low perioperative fluid volumes were associated with an increase in complications after noncardiac surgery.Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.

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