• Hiroyasu Koizumi, Eiichi Suehiro, Yuichi Fujiyama, Hiroshi Yoneda, Hideyuki Ishihara, Sadahiro Nomura, Masami Fujii, and Michiyasu Suzuki.
• Department of Neurosurgery, Yamaguchi University School of Medicine, Yamaguchi, Japan. hiroyasu@yamaguchi-u.ac.jp.
• Acta Neurochir. Suppl. 2016 Jan 1; 122: 193-7.

AbstractThe pressure reactivity index (PRx) is calculated as a moving correlation coefficient between intracranial pressure (ICP) and mean arterial blood pressure (MABP), and this analytical value is viewed as reflecting a vasomotor response to MABP variability. At present, the factors influencing the PRx value during the acute stage of traumatic brain injury (TBI) are not known. We observed significant cases where changes in the calculated value of PRx seemed to be influenced by changes in brain temperature during the course of acute stage TBI. In one case, a patient was treated for 72 h with therapeutic brain hypothermia after a decompressive hemicraniectomy. During the hypothermic condition, the mean value of PRx was -0.019; however, after gradual rewarming, the value of PRx increased drastically, and the mean value during the rewarming period, when the brain temperature exceeded 35 °C, was 0.331. Similarly, in another case where the patient underwent therapeutic brain hypothermia, the PRx showed a mean value of -0.038 during the hypothermic condition, and a mean value of 0.052 during the rewarming period. In both cases, a trend toward a negative correlation between ICP and MABP during brain hypothermia shifted to a positive correlation upon rewarming.

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