• Current medical science · Apr 2020

    Clinical Characteristics of Children with Coronavirus Disease 2019 in Hubei, China.

    • Fang Zheng, Chun Liao, Qi-Hong Fan, Hong-Bo Chen, Xue-Gong Zhao, Zhong-Guo Xie, Xi-Lin Li, Chun-Xi Chen, Xiao-Xia Lu, Zhi-Sheng Liu, Wei Lu, Chun-Bao Chen, Rong Jiao, Ai-Ming Zhang, Jin-Tang Wang, Xi-Wei Ding, Yao-Guang Zeng, Li-Ping Cheng, Qing-Feng Huang, Jiang Wu, Xi-Chang Luo, Zhu-Jun Wang, Yan-Yan Zhong, Yan Bai, Xiao-Yan Wu, and Run-Ming Jin.
    • Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China.
    • Curr Med Sci. 2020 Apr 1; 40 (2): 275-280.

    AbstractSince December 2019, COVID-19 has occurred unexpectedly and emerged as a health problem worldwide. Despite the rapidly increasing number of cases in subsequent weeks, the clinical characteristics of pediatric cases are rarely described. A cross-sectional multicenter study was carried out in 10 hospitals across Hubei province. A total of 25 confirmed pediatric cases of COVID-19 were collected. The demographic data, epidemiological history, underlying diseases, clinical manifestations, laboratory and radiological data, treatments, and outcomes were analyzed. Of 25 hospitalized patients with COVID-19, the boy to girl ratio was 1.27:1. The median age was 3 years. COVID-19 cases in children aged <3 years, 3.6 years, and ≥6-years patients were 10 (40%), 6 (24%), and 9 (36%), respectively. The most common symptoms at onset of illness were fever (13 [52%]), and dry cough (11 [44%]). Chest CT images showed essential normal in 8 cases (33.3%), unilateral involvement of lungs in 5 cases (20.8%), and bilateral involvement in 11 cases (45.8%). Clinical diagnoses included upper respiratory tract infection (n=8), mild pneumonia (n=15), and critical cases (n=2). Two critical cases (8%) were given invasive mechanical ventilation, corticosteroids, and immunoglobulin. The symptoms in 24 (96%) of 25 patients were alleviated and one patient had been discharged. It was concluded that children were susceptible to COVID-19 like adults, while the clinical presentations and outcomes were more favorable in children. However, children less than 3 years old accounted for majority cases and critical cases lied in this age group, which demanded extra attentions during home caring and hospitalization treatment.

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