• Xinying Xue, Hui Deng, Longting Zhao, Xuelei Zang, Idorenyin Polycarp Asuquo, Mingming Meng, Xidong Ma, Chong Qin, Yao Meng, Chongchong Wu, Jie Gao, and Lei Pan.
• Department of Respiratory and Critical Care, Beijing Shijitan Hospital, Capital Medical University.
• Medicine (Baltimore). 2020 Dec 11; 99 (50): e23213e23213.

AbstractCryptococcosis caused by Cryptococcus gattii, is a life threatening fungal infection with recently increasing prevalence. C. gattii is a species complex comprising multiple independent species. However, many biological characteristics and clinical features of cryptococcosis due to C. gattii are relatively less well defined. In this paper, we identify two cases of C. gattii infection, and laboratory findings of genotype VGI and VGII in two groups of apparently immunocompetent Chinese individuals respectively. Upon detailed review of all 35 cases of C. gattii infections, it was observed that C. gattii can cause debilitating illness in both immunocompetent and immunocompromised individuals. Cryptococcosis due to C. gattii is a serious systemic fungal infection, with pulmonary central nervous system tropism. Epidemiologically, C. gattii infection is not only restricted in tropical and subtropical regions, but also in other geographical settings.

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