• Qi Wang, He Yan, Rangrang Wang, Chunyan Li, Wei Li, Yanling Xu, Zhenzhong Su, and Jie Zhang.
• Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Jilin University.
• Medicine (Baltimore). 2020 Dec 11; 99 (50): e23501.

IntroductionPrimary pulmonary lymphoma (PPL) is a rare extranodal lymphoma. Only 5% to 20% of patients suffering from PPL have diffuse large β-cell lymphoma (DLBCL), and their chest computed tomography (CT) findings show single- or double-lung patchy or flocculated shadows, isolated or multifocal nodules, or masses. In this research paper, we report an older woman having multiple ground-glass nodules, who was eventually diagnosed with primary pulmonary diffuse large β-cell lymphoma (PPDLBCL).Patient ConcernsA 69-year-old woman suffering from cough was admitted to the Second Hospital of Jilin University.DiagnosesA chest CT scan showed multiple ground-glass nodules. She had received 2 weeks of antibiotic treatment, but the multiple ground-glass nodules were still present. Lung biopsy was performed by tracheoscopy, which showed non-Hodgkin diffuse large β-cell lymphoma.InterventionsThe patient received R-CHOP-21 chemotherapy.OutcomesThe multiple ground-glass nodules were absorbed.ConclusionThe current study shows that spotting multiple ground-glass nodules in the lungs is a clear indication of the presence of PPDLBCL. It is important to spread awareness of PPDLBCL, which needs timely diagnosis and management.

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