• Medicine · Dec 2020

    Meta Analysis

    Effects of intermittent feeding versus continuous feeding on enteral nutrition tolerance in critically ill patients: A protocol for systematic review and meta-analysis.

    • Yuanli Li, Jin Yang, Shunxia Sun, Juan Huang, Aiguo Zhang, and Xiaoling Tang.
    • Department of Critical Care Unit, Chongqing General Hospital, Chomgqing, China.
    • Medicine (Baltimore). 2020 Dec 11; 99 (50): e23528e23528.

    BackgroundNutritional support is an indispensable treatment for critically ill patients. Enteral nutrition intolerance is one of the obstacles to the smooth progress of enteral nutrition.Enteral nutrition can be divided into continuous feeding and intermittent feeding. However, the effectiveness and safety of the 2 ways of nutrition infusion are controversial clinically. Therefore, this meta-analysis further evaluated the effect of intermittent feeding versus continuous feeding on enteral nutrition tolerance in critically ill patients.MethodsCochrane Library, PubMed, Web of Science, EMbase, China Biology Medicine disc (CBM), China Science and Technology Journal Database (VIP), China Journal full-text Database (CNKI), and Wanfang Database were searched for all randomized controlled trials (RCTs) on the effects of intermittent and continuous feeding on enteral nutrition tolerance in critically ill patients. The quality of literatures was strictly evaluated and the data were extracted by 2 investigators. Meta-analysis was carried out by applying RevMan 5.5 software.ResultsThe results of this meta-analysis are published in peer-reviewed journals.ConclusionsThis study provides reliable evidence-based support for the effects of intermittent and continuous feeding on enteral nutrition tolerance in critically ill patients.Osf Registration NumberDOI 10.17605/OSF.IO/4BP5X.

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