• Sihan Peng, Xiyu Zhang, Ya Liu, Xiaoxu Fu, Mingyang Zhou, Gang Xu, and Chunguang Xie.
• Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China/ Chengdu University of Traditional Chinese Medicine, Chengdu, China.
• Medicine (Baltimore). 2020 Dec 11; 99 (50): e23622e23622.

BackgroundSenile diabetes with depression is a common and frequently-occurring disease, and it is also a difficult and hot point in domestic and international research. However, the efficiency of combination hypoglycemic agents and antidepressants in the treatment of senile diabetes with depression is poor, and new intervention methods are urgently needed. Research shows the 5-element therapy, as a Chinese traditional non-drug intervention, has definite curative effect on the prevention and treatment of various physical and mental diseases. The purpose of this systematic review and meta-analysis is to evaluate the efficacy of 5-element therapy on senile diabetes with depression.MethodsThe electronic databases including Pubmed, Embase, Cochrane Library, Web of science, Chinese National Knowledge Infrastructure, Wanfang Database, Sino Med,China Biomedical Literature Database will be searched. The time limit for retrieving studies is from establishment to October 2020 for each database. Randomized controlled clinical trials related to 5-element therapy intervention on senile diabetes with depression will be included. Stata V.13.0 and Review manager 5.3 software will be implemented for data synthesis, sensitivity analysis, subgroup analysis, and the assessment of bias risk. We will use the grading of recommendations assessment, development, and evaluation system to assess the quality of evidence.ResultsThis study will provide a quantitative and standardized evaluation for the efficacy of 5-element therapy on senile diabetes with depression.ConclusionThis systematic review and meta-analysis will provide the high-quality evidence to assess whether the 5-element therapy has a positive treatment effect for senile diabetes with depression.Registration NumberINPLASY2020100081.

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