• S. Afr. Med. J. · Dec 2020

    Review

    The impact of obesity on the cellular and molecular pathophysiology of COVID-19.

    • P Dhanraj, R Pitere, and M S Pepper.
    • Department of Immunology, Institute for Cellular and Molecular Medicine, SAMRC Extramural Unit for Stem Cell Research and Therapy, Faculty of Health Sciences, University of Pretoria, South Africa. michael.pepper@up.ac.za.
    • S. Afr. Med. J. 2020 Dec 14; 0 (0): 13184.

    AbstractEmerging evidence reveals a strong association between COVID-19 and obesity in terms of disease severity, need for hospitalisation and risk of mortality. In this review, we discuss cellular and molecular mechanisms potentially contributing to the pathophysiology of COVID-19 in obese patients. Understanding the relationship between COVID-19 and obesity is pertinent for the clinical management of these patients.

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