• Arch. Dis. Child. · Feb 1999

    Case Reports

    Mannitol and frusemide in the treatment of diuretic resistant oedema in nephrotic syndrome.

    • M A Lewis and A Awan.
    • Department of Paediatric Nephrology, Royal Manchester Children's Hospital, Pendlebury, UK. malewis@breathe.co.uk
    • Arch. Dis. Child. 1999 Feb 1; 80 (2): 184-5.

    AbstractThree children (two girls aged 7 and 9 years, and one boy aged 4 years) with diuretic resistant oedema in steroid resistant nephrotic syndrome were treated with a combination of intravenous mannitol and frusemide. All three responded with loss of oedema of 10% to 30% of body weight over one week. There were no complications of hypertension or hypovolaemia. Mannitol-frusemide combination is a safe, inexpensive, and effective treatment for diuretic resistant oedema. Its use in other conditions and in developing countries (where the availability and purity of 20% albumin is limited) needs to be explored.

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