• Long Zhou, Jinhuang Lin, Junming Lin, Guoju Kui, Jianhua Zhang, and Yigang Yu.
• Affiliated Dongnan Hospital of Xiamen University, the 175 Hospital of Chinese PLA, Trauma Neurosurgery Center of Nanjing Military Region, Xiamen, Fujian Province, China.
• Neural Regen Res. 2014 Sep 1; 9 (17): 1585-91.

AbstractPrevious studies have shown that vagus nerve stimulation can improve the prognosis of traumatic brain injury. The aim of this study was to elucidate the mechanism of the neuroprotective effects of vagus nerve stimulation in rabbits with brain explosive injury. Rabbits with brain explosive injury received continuous stimulation (10 V, 5 Hz, 5 ms, 20 minutes) of the right cervical vagus nerve. Tumor necrosis factor-α, interleukin-1β and interleukin-10 concentrations were detected in serum and brain tissues, and water content in brain tissues was measured. Results showed that vagus nerve stimulation could reduce the degree of brain edema, decrease tumor necrosis factor-α and interleukin-1β concentrations, and increase interleukin-10 concentration after brain explosive injury in rabbits. These data suggest that vagus nerve stimulation may exert neuroprotective effects against explosive injury via regulating the expression of tumor necrosis factor-α, interleukin-1β and interleukin-10 in the serum and brain tissue.

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