• Rev Med Interne · Mar 2020

    Review Case Reports

    [A new case of rare erythrocytosis due to EGLN1 mutation with review of the literature].

    • A Bonnin, B Gardie, F Girodon, F Airaud, C Garrec, S Bézieau, G Vignon, P Mottaz, J Labrousse, and F Lellouche.
    • Service de médecine interne, centre hospitalier de Royan, 20, avenue de Saint-Sordelin, 17640 Vaux sur mer, France.
    • Rev Med Interne. 2020 Mar 1; 41 (3): 196-199.

    IntroductionThe origin of polycythemia is often simple to detect. Sometimes it is necessary to look for hereditary forms, the decisive parameters being the dosage of erythropoietin and the measurement of the oxygen dissociation curve (P50). These rare diseases are related to high oxygen-affinity haemoglobins, abnormalities of the erythropoietin receptor or dysfunction of the HIF (hypoxia-inducible factor) pathway.Case ReportWe report the case of a 56-year-old patient with unexplained polycythemia associated with normal serum erythropoietin and normal P50, in whom the never previously described mutation c.400C>T(p.Gln134*) on exon 1 in the EGLN1 gene (encoding PHD2) was found.ConclusionIn the face of an unexplained polycythemia a good cooperation between clinicians and biologists is necessary to be able to characterize rare hereditary pathologies.Copyright © 2020 Société Nationale Française de Médecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

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