• Eur J Emerg Med · Jun 2021

    Multicenter Study Observational Study

    Association between acute heart failure and major cardiovascular events in atrial fibrillation patients presenting at the emergency department: an EMERG-AF ancillary study.

    • Blanca Coll-Vinent, Mercedes Varona, Alfonso Martin, José Carbajosa, Juan Sánchez, Juan Tamargo, Manuel Cancio, Susana Sánchez, Carmen Del Arco, Òscar Miró, José Ríos, Ana García, Amparo Fernández-Simón, Natalia Miota, Coral Suero, and EMERG-AF investigators (Appendix 1).
    • Arrhythmia Division, Spanish Society of Emergency Medicine (SEMES).
    • Eur J Emerg Med. 2021 Jun 1; 28 (3): 210-217.

    BackgroundThere is little evidence concerning the impact of acute heart failure (AHF) on the prognosis of atrial fibrillation patients attending the emergency department (ED).ObjectiveTo know the influence of AHF on adverse long-term outcomes in patients presenting with atrial fibrillation in ED.Design, Setting And ParticipantsSecondary analysis of a prospective, multicenter, observational cohort of consecutive atrial fibrillation patients, performed in 62 Spanish EDs.ExposurePatients presenting with atrial fibrillation in ED were divided by the presence or absence of AHF at arrival.Outcome Measures And AnalysisPrimary outcome: combination of 1-year all-cause mortality, major bleeding, stroke and other major cardiovascular events (MACE). Secondary outcomes: each of these events analyzed separately. Cox and logistic regression were used to investigate adjusted significant associations between AHF and outcomes.Main ResultsTotally, 1107 consecutive ED patients with atrial fibrillation attending ED were analyzed, 262 (23.7%) with AHF. The primary outcome occurred in 433 patients (39.1%), 1-year all-cause mortality in 151 patients (13.6%), major bleeding in 47 patients (4.2 %), stroke in 31 patients (2.8 %) and other MACE in 333 patients (30.1%). AHF was independently related to the primary outcome [odds ratio (OR), 1.422; 95% confidence interval (CI), 1.020-1.981; P = 0.037)] and 1-year MACE (OR, 1.797; 95% CI, 1.285-2.512; P = 0.001), but not to 1-year all-cause mortality, stroke or bleeding.ConclusionsThe coexistence of AHF in patients presenting with atrial fibrillation in ED is associated to a worse 1-year outcome mainly due to MACE, but does not impact in overall mortality.Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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