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- Emma Rybalka, Craig A Goodman, Dean G Campelj, Alan Hayes, and Cara A Timpani.
- Institute for Health and Sport, Victoria University, Melbourne, Australia.
- Curr Med Res Opin. 2021 Mar 1; 37 (3): 465-467.
AbstractAdenylosuccinic acid (ASA) modifies Duchenne muscular dystrophy (DMD) progression in dystrophic mdx mice and human DMD patients. Despite an established role for ASA in augmenting metabolism and cellular energy homeostasis, our previous data suggests an undiscovered ulterior mode of action capable of modifying DMD disease course. Here, we identify ASA as a novel inducer of nuclear factor erythroid 2-related factor-2 (Nrf2), master regulator of the antioxidant and cytoprotective response to cell stress.
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