• Der Internist · May 2021

    Case Reports

    [Metabolic acidosis of surprising origin in a 61-year-old female patient].

    • T F Koyro, T Thottakara, T B Huber, and S Harendza.
    • III. Medizinische Klinik und Poliklinik, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Deutschland. t.koyro@uke.de.
    • Internist (Berl). 2021 May 1; 62 (5): 549-554.

    AbstractA 61-year-old female patient presented to the emergency room with nausea. Laboratory findings revealed metabolic acidosis, which had to be associated with a sodium-glucose co-transporter‑2 (SGLT2) inhibitor. Due to increasing prescription rates of SGLT2 inhibitors for diabetes mellitus, congestive heart failure or chronic renal insufficiency, a growing numbers of cases of SGLT2 inhibitor-associated ketoacidosis should be expected. Calculating the anion gap can provide orientation in the case of acidosis of unknown origin. Presumably, a relevant proportion of such cases of ketoacidosis is currently being overlooked or its diagnosis delayed.

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