• Carla Solange Escórcio-Dourado, Francisco Adelton Alves-Ribeiro, Jose Charles Lima-Dourado, Dos SantosAlesse RibeiroAR0000-0002-1792-0925Programa de Pos-Graduacao da Rede Nordeste de Biotecnologia (RENORBIO), Nordeste, Universidade Federal do Piaui, Teresina, PI, BR., de Oliveira PereiraRenatoR0000-0003-4423-1575Programa de Pos-Graduacao da Rede Nordeste de Biotecnologia (RENORBIO), Nordeste, Universidade Federal do Piaui, Teresina, PI, BR., Cleciton Braga Tavares, Vladimir Costa Silva, Pedro Vitor Lopes Costa, José Maria Soares-Júnior, and da SilvaBenedito BorgesBB0000-0002-9542-7538Programa de Pos-Graduacao da Rede Nordeste de Biotecnologia (RENORBIO), Nordeste, Universidade Federal do Piaui, Teresina, PI, BR.Programa de Pos-Graduacao em Ciencias Medicas, Universidade Federal do Piaui, Ter.
• Programa de Pos-Graduacao da Rede Nordeste de Biotecnologia (RENORBIO), Nordeste, Universidade Federal do Piaui, Teresina, PI, BR.
• Clinics (Sao Paulo). 2020 Jan 1; 75: e2360e2360.

ObjectivesIn the Human Epidermal Growth Factor Receptor-2 (HER2) rs1136201 variant, the presence of the G allele may promote cellular alterations and increase breast cancer risk, in addition to enhanced cellular proliferation, tumor aggressiveness, and metastases. The aim of this study was to investigate the presence of the single-nucleotide polymorphism (SNP) variant, rs1136201, within the HER2 gene in women from the Northeastern region of Brazil and breast cancer risk.MethodsThe study included 140 women who were divided into two groups, case (breast cancer) and control (without breast cancer), with 70 women in each group. Peripheral blood of each woman was drawn for the study of genomic Deoxyribonucleic acid (DNA) extracted from leukocytes using the genotyping technique by real-time polymerase chain reaction.ResultsThe GG genotype occurred in 1 woman in both groups (1.4%) (p=0.32), while the AG genotype occurred in 19 (27.2%) and 13 (18.6%) women in the case and control (p=1.00) groups, respectively. No statistically significant difference in GG and AG genotypes was observed between the case and control groups in premenopausal women (p=1.00). Furthermore, no significant difference in genotypes was observed between the groups, among postmenopausal women (p=0.14).ConclusionIn this study, the HER2 rs1136201 polymorphism did not show any statistically significant association with breast cancer, both in premenopausal and postmenopausal women. Nevertheless, further studies with a larger sample size should be performed to assess the association of HER2 polymorphism with breast cancer risk in women from the Northeastern region of Brazil.

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