Treating Hallucinations and Delusions Associated With

Curr Psychiatry Rep · Jan 2018

Review

Treating Hallucinations and Delusions Associated With Parkinson's Disease Psychosis.

We discuss features of Parkinson's disease psychosis (PDP) including symptomology and pathophysiology. Treatment options, including non-pharmacologic strategies, dose reduction of offending agents, and the addition of non-dopaminergic antipsychotics, are addressed. The efficacy of second-generation antipsychotics and novel agents is examined. ⋯ Pimavanserin, a 5-HT2A/C receptor inverse agonist with no other receptor activity, has shown efficacy and tolerability and is now FDA approved for PDP treatment. Research into novel targets is ongoing. PDP is a morbid complication of Parkinson's disease with complex incompletely understood mechanisms. Treatment is directed towards mitigation of psychosis without worsening of motor features.

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- Shyam C Panchal and William G Ondo.
- Department of Neurology, Houston Methodist Neurological Institute, 6560 Fannin Street; Scurlock Tower, Suite 802, Houston, TX, 77030, USA. spanchal@houstonmethodist.org.
- Curr Psychiatry Rep. 2018 Jan 27; 20 (1): 3.
Purpose Of ReviewWe discuss features of Parkinson's disease psychosis (PDP) including symptomology and pathophysiology. Treatment options, including non-pharmacologic strategies, dose reduction of offending agents, and the addition of non-dopaminergic antipsychotics, are addressed. The efficacy of second-generation antipsychotics and novel agents is examined.Recent FindingsPimavanserin, a 5-HT2A/C receptor inverse agonist with no other receptor activity, has shown efficacy and tolerability and is now FDA approved for PDP treatment. Research into novel targets is ongoing. PDP is a morbid complication of Parkinson's disease with complex incompletely understood mechanisms. Treatment is directed towards mitigation of psychosis without worsening of motor features.

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Treating Hallucinations and Delusions Associated With Parkinson's Disease Psychosis.

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