• Int. J. Cardiol. · Mar 2017

    Randomized Controlled Trial Multicenter Study

    Ideal cardiovascular health in childhood-Longitudinal associations with cardiac structure and function: The Special Turku Coronary Risk Factor Intervention Project (STRIP) and the Cardiovascular Risk in Young Finns Study (YFS).

    • Tomi T Laitinen, Saku Ruohonen, Markus Juonala, Costan G Magnussen, Vera Mikkilä, Hanna Mikola, Nina Hutri-Kähönen, Tomi Laitinen, Päivi Tossavainen, Eero Jokinen, Harri Niinikoski, Antti Jula, Jorma S A Viikari, Tapani Rönnemaa, Olli T Raitakari, and Katja Pahkala.
    • Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Paavo Nurmi Centre, Sports & Exercise Medicine Unit, Department of Physical Activity and Health, University of Turku, Turku, Finland. Electronic address: tomi.laitinen@utu.fi.
    • Int. J. Cardiol. 2017 Mar 1; 230: 304-309.

    BackgroundIdeal cardiovascular health (CVH), defined by the American Heart Association, is associated with incident cardiovascular disease in adults. However, association of the ideal CVH in childhood with current and future cardiac structure and function has not been studied.Methods And ResultsThe sample comprised 827 children participating in the longitudinal Special Turku Coronary Risk Factor Intervention Project (STRIP) and The Cardiovascular Risk in Young Finns Study (YFS). In STRIP, complete data on the seven ideal CVH metrics and left ventricular (LV) mass measured with echocardiography were available at the age of 15 (n=321), 17 (n=309) and 19 (n=283) years. In YFS, the cohort comprised children aged 12-18years (n=506) with complete ideal CVH metrics data from childhood and 25years later in adulthood, and echocardiography performed in adulthood. In STRIP, ideal CVH score was inversely associated with LV mass during childhood (P=0.036). In YFS, childhood ideal CVH score was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume in adulthood (all P<0.01). In addition, improvement of the ideal CVH score between childhood and adulthood was inversely associated with LV mass, LV end-diastolic volume, E/e' ratio, and left atrium end-systolic volume (all P≤0.03).ConclusionsChildhood ideal CVH score has a long-lasting effect on cardiac structure and function, and the association is evident already in childhood. Our findings support targeting the ideal CVH metrics as part of primordial prevention of cardiovascular diseases.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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