• Virus research · Dec 2014

    Review

    Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein.

    • Shuai Xia, Qi Liu, Qian Wang, Zhiwu Sun, Shan Su, Lanying Du, Tianlei Ying, Lu Lu, and Shibo Jiang.
    • Key Lab of Medical Molecular Virology of MOE/MOH, Shanghai Medical College, Fudan University, 130 Dong An Road, Xuhui District, Shanghai 200032, China.
    • Virus Res. 2014 Dec 19; 194: 200-10.

    AbstractThe recent outbreak of Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) infection has led to more than 800 laboratory-confirmed MERS cases with a high case fatality rate (∼35%), posing a serious threat to global public health and calling for the development of effective and safe therapeutic and prophylactic strategies to treat and prevent MERS-CoV infection. Here we discuss the most recent studies on the structure of the MERS-CoV spike protein and its role in virus binding and entry, and the development of MERS-CoV entry/fusion inhibitors targeting the S1 subunit, particularly the receptor-binding domain (RBD), and the S2 subunit, especially the HR1 region, of the MERS-CoV spike protein. We then look ahead to future applications of these viral entry/fusion inhibitors, either alone or in combination with specific and nonspecific MERS-CoV replication inhibitors, for the treatment and prevention of MERS-CoV infection. Copyright © 2014 Elsevier B.V. All rights reserved.

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