• Kavrut OzturkNilgunNUniversity of Health Sciences Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation, Antalya, Turquia. Electronic address: kavrut@yahoo.com., Ali Sait Kavakli, Ulku Arslan, Guzin Aykal, and Murat Savas.
• University of Health Sciences Antalya Training and Research Hospital, Department of Anesthesiology and Reanimation, Antalya, Turquia. Electronic address: kavrut@yahoo.com.
• Rev Bras Anestesiol. 2020 Nov 1; 70 (6): 573-582.

BackgroundThe present study investigated the association between Postoperative Cognitive Dysfunction (POCD) and increased serum S100B level after Robotic-Assisted Laparoscopic Radical Prostatectomy (RALRP).MethodsThe study included 82 consecutive patients who underwent RALRP. Serum S100B levels were determined preoperatively, after anesthesia induction, and at 30 minutes and 24 hours postoperatively. Cognitive function was assessed using neuropsychological testing preoperatively and at 7 days and 3 months postoperatively.ResultsTwenty-four patients (29%) exhibited POCD 7 days after surgery, and 9 (11%) at 3 months after surgery. Serum S100B levels were significantly increased at postoperative 30minutes and 24 hours in patients displaying POCD at postoperative 7 days (p = 0.0001 for both) and 3 months (p = 0.001 for both) compared to patients without POCD. Duration of anesthesia was also significantly longer in patients with POCD at 7 days and 3 months after surgery compared with patients without POCD (p = 0.012, p = 0.001, respectively), as was duration of Trendelenburg (p = 0.025, p = 0.002, respectively). Composite Z score in tests performed on day 7 were significantly correlated with duration of Trendelenburg and duration of anesthesia (p = 0.0001 for both).ConclusionsS100B increases after RALRP and this increase is associated with POCD development. Duration of Trendelenburg position and anesthesia contribute to the development of POCD.Trial Registry NumberClinicaltrials.gov (N° NCT03018522).Copyright © 2020 Sociedade Brasileira de Anestesiologia. Publicado por Elsevier Editora Ltda. All rights reserved.

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