• Clin Drug Investig · Mar 2013

    17 α-hydroxyprogesterone caproate (Makena®): a guide to its use in the prevention of preterm birth.

    • Mary Hines, Katherine A Lyseng-Williamson, and Emma D Deeks.
    • Adis, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, North Shore, 0754, Auckland, New Zealand.
    • Clin Drug Investig. 2013 Mar 1; 33 (3): 223-7.

    AbstractIntramuscular 17 α-hydroxyprogesterone caproate (Makena(®)), a synthetic progestin, is indicated to reduce the risk of preterm birth in women with a singleton pregnancy who have a history of a singleton spontaneous preterm birth. Makena(®) reduces the risk of preterm birth in this patient population, and is associated with improvements in certain fetal/neonatal outcomes. The use of this US FDA-approved formulation of 17 α-hydroxyprogesterone caproate reduces the inherent risks associated with the use of pharmacy-compounded formulations of the drug.

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