Simultaneous subependymomas in monozygotic female twins:

Journal of neurosurgery · Sep 2014

Case Reports

Simultaneous subependymomas in monozygotic female twins: further evidence for a common genetic or developmental disorder background.

In this paper, a rare case of subependymoma of the fourth ventricle in identical female twins is reported. Magnetic resonance imaging and CT showed nearly identical locations of the tumors in the fourth ventricle and similar growth patterns of the tumors in both sisters. ⋯ If symptomatic, a subependymoma can in some cases lead to sudden death caused by pressure on the brainstem or decompensated secondary hydrocephalus. This case demonstrates the importance of detecting tumors early and thereby preventing symptoms arising from increasing intracranial pressure, and optimizing therapy options.

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- Susan Noell, Rudi Beschorner, Sotirios Bisdas, Ulrike Beyer, Ruthild G Weber, Petra Fallier-Becker, and Rainer Ritz.
- Departments of Neurosurgery.
- J. Neurosurg.. 2014 Sep 1;121(3):570-5.
AbstractIn this paper, a rare case of subependymoma of the fourth ventricle in identical female twins is reported. Magnetic resonance imaging and CT showed nearly identical locations of the tumors in the fourth ventricle and similar growth patterns of the tumors in both sisters. Likewise, postoperative histopathological analysis of both tumors revealed the typical histological appearance of subependymomas. Subependymoma is a rare, low-grade glioma of the CNS, slowly growing and usually asymptomatic. If symptomatic, a subependymoma can in some cases lead to sudden death caused by pressure on the brainstem or decompensated secondary hydrocephalus. This case demonstrates the importance of detecting tumors early and thereby preventing symptoms arising from increasing intracranial pressure, and optimizing therapy options.

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Simultaneous subependymomas in monozygotic female twins: further evidence for a common genetic or developmental disorder background.

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